Alzheimer's disease : life course perspectives on risk by Amy Borenstein, James Mortimer

By Amy Borenstein, James Mortimer

Alzheimer's disorder: Lifecourse views on hazard aid summarizes the growing to be physique of information at the distribution and reasons of Alzheimer’s disorder (AD) in human populations, offering the reader with wisdom on how we outline the illness and what its probability and protecting components are within the context of a life-course strategy.

At the realization of the e-book, the reader will comprehend why Alzheimer’s affliction most probably starts off at notion, then progresses via early-life and grownup probability components that finally influence the stability among pathologic insults within the mind and the facility of the mind to switch illness indicators. unlike edited volumes which can have little solidarity, this publication specializes in an built-in life-course method of the epidemiology of dementia, specifically, Alzheimer’s illness.

  • Reviews the present technological know-how surrounding Alzheimer’s disease
  • Provides a primer of foundational wisdom at the disease's epidemiology and biostatistics
  • Utilizes a life-course process, supplying a singular and built-in view of the evolution of this ailment from genes to mind reserve
  • Uses the ‘threshold model’—a idea first defined by means of Dr. Mortimer and broadly accredited today—which accommodates the belief of probability components for the pathology and expression of the ailment
  • Proposes that enhancing mind future health via modifiable behaviors can hold up illness onset till a later age
  • Examines the way forward for prevention of Alzheimer’s ailment, a topic of serious present interest

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Extra info for Alzheimer's disease : life course perspectives on risk reduction

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Therefore, it can be argued that, while stratification by education would improve test validity, it would partially or completely reduce the ability to study education as an etiologic factor for dementia and AD (Mortimer & Graves, 1993). Most investigators have decided not to stratify the cut-scores by education in an effort to allow the association between education, cognition and the occurrence of AD to be examined. Before concluding this chapter, a few words should be mentioned about the detection of prevalent versus incident cases and about detecting MCI or prodromal dementia versus AD in epidemiologic studies.

In the first phase, the population was screened with a relatively short global cognitive test, such as the Mini-Mental Screening Examination. Those who scored below a predetermined cutoff point Epidemiologic Definition of a Case Chapter | 3 27 on the test were referred to a more comprehensive assessment, typically involving a complete clinical history and evaluation, neurologic examination, administration of a detailed neuropsychological battery, blood tests to rule out reversible causes of dementia, and imaging to rule out tumors and to observe markers of cerebrovascular disease and other contributing factors.

NaMCI-single domain, the least common type, is associated with frontotemporal dementia and dementia with Lewy bodies (Petersen, 2004). Therefore, the MCI sub-diagnosis may assist the physician and patient in determining what the eventual outcome will be. What was viewed in the 1980s and 1990s as a dichotomous state (demented or not demented) and later as three distinct states (normal, MCI, and AD) is now recognized as a continuous cognitive trajectory. 2 Cognitive continuum showing the overlap between normal aging, mild cognitive impairment, and Alzheimer’s disease.

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